Standard Article

Gut Tachykinins

Handbook of Physiology, The Gastrointestinal System, Neural and Endocrine Biology

  1. John E Maggio1,
  2. Patrick W Mantyh2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060227

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Maggio, J. E. and Mantyh, P. W. 2011. Gut Tachykinins. Comprehensive Physiology. 661–690.

Author Information

  1. 1

    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts

  2. 2

    Department of Medicine, University of California School of Medicine, Los Angeles, California

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Discovery and Early Studies of Tachykinins
    • 1.1
      Discovery of Substance P
    • 1.2
      Discovery of Nonmammalian Tachykinins
    • 1.3
      Rediscovery of Substance P
    • 1.4
      Caveats for Interpretation of Substance P Research
  • 2
    Pharmacology and Physiology of Substance P
    • 2.1
      Structure-Activity Relationships
    • 2.2
      Biosynthesis
    • 2.3
      Release
    • 2.4
      Receptors and Second Messengers
    • 2.5
      Spasmogenic Activity
    • 2.6
      Conduction of Nociceptive Information
    • 2.7
      Hemodynamic Regulation
    • 2.8
      Exocrine Effects
    • 2.9
      Endocrine Effects
    • 2.10
      Pathology
  • 3
    Distribution and Location of Tachykinins in the Gastrointestinal Tract
    • 3.1
      Caveats
    • 3.2
      Location of Fibers and Cells Containing Substance P-Like Immunoreactivity in the Gastrointestinal Tract
    • 3.3
      Location of Substance P Receptors in the Gastrointestinal Tract
    • 3.4
      Pancreas
    • 3.5
      Salivary Glands
  • 4
    Ontogeny and Phylogeny
    • 4.1
      Ontogeny
    • 4.2
      Phylogeny
  • 5
    Recent Developments
    • 5.1
      Discovery of Novel Mammalian Tachykinins
    • 5.2
      Pharmacology of Substance K and Neuromedin K
    • 5.3
      Tissue Distribution of Novel Mammalian Tachykinins
    • 5.4
      Characteristics of Binding Sites for Novel Mammalian Tachykinins
  • 6
    Mode of Action of Tachykinins
  • 7
    Conclusions
  • 8
    Addendum
    • 8.1
      Nomenclature
    • 8.2
      Novel Tachykinins
    • 8.3
      Molecular Biology
    • 8.4
      Binding and Autoradiography
    • 8.5
      Tachykinin Receptor-Binding Sites in the Canine Gastrointestinal Tract
    • 8.6
      Tachykinins, Tachykinin Receptors, and Inflammatory Bowel Disease