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Biochemistry of Gastric Acid Secretion: H+-K+-ATPase

Handbook of Physiology, The Gastrointestinal System, Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion

  1. G. Sachs1,
  2. J. Kaunitz1,
  3. J. Mendlein2,
  4. B. Wallmark3

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060312

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Sachs, G., Kaunitz, J., Mendlein, J. and Wallmark, B. 2011. Biochemistry of Gastric Acid Secretion: H+-K+-ATPase. Comprehensive Physiology. 229–253.

Author Information

  1. 1

    Center for Ulcer Research and Education, Wadsworth Veterans Administration Hospital and University of California, Los Angeles, California

  2. 2

    Department of Physiology, University of California School of Medicine, Los Angeles, California

  3. 3

    Hassle AB, Molndahl, Sweden

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Parietal Cell Acid Secretion and H+-K+-ATPASE
  • 2
    General Aspects of H+-K+-ATPASE
  • 3
    Structure of H+-K+-ATPASE
    • 3.1
      Sequence
    • 3.2
      Protein Composition
    • 3.3
      Dimensions
  • 4
    Transport by H+-K+-ATPASE
    • 4.1
      Resting Vesicles
    • 4.2
      Stimulated Vesicles
    • 4.3
      Transport Modes of H+-K+-ATPase
    • 4.4
      H+-K+-ATPase in Parietal Cell
  • 5
    Kinetics of H+-K+-ATPASE
    • 5.1
      Steady-State Kinetics of ATPase
    • 5.2
      Steady-State Kinetics of Phosphatase Reaction
    • 5.3
      Phosphorylation from ATP
    • 5.4
      ATP-ADP Exchange
    • 5.5
      Potassium-Dependent Dephosphorylation
    • 5.6
      Phosphorylation from Pi
  • 6
    Conformations of H+-K+-ATPASE
    • 6.1
      Tryptic Digestion
    • 6.2
      Fluorescence
  • 7
    Inhibition of H+-K+-ATPASE
    • 7.1
      Site-Specific Inhibitors
    • 7.2
      Group-Selective Reagents
  • 8
    Biosynthesis of H+-K+-ATPASE
  • 9
    Tissue Distribution of H+-K+-ATPASE
  • 10
    Model for H+-K+-ATPASE