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Secretion of Bicarbonate by Gastric and Duodenal Mucosa

Handbook of Physiology, The Gastrointestinal System, Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion

  1. Gunnar Flemström1,
  2. Andrew Garner2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060316

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Flemström, G. and Garner, A. 2011. Secretion of Bicarbonate by Gastric and Duodenal Mucosa. Comprehensive Physiology. 309–326.

Author Information

  1. 1

    Department of Physiology and Medical Biophysics, Uppsala University Medical Center, Uppsala, Sweden

  2. 2

    Department of Bioscience, ICI Pharmaceuticals Division, Macclesfield, England

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Methods of Measurement
    • 1.1
      Gastric Bicarbonate Secretion
    • 1.2
      Duodenal Bicarbonate Secretion
  • 2
    Mechanisms of Gastroduodenal Bicarbonate Secretion
    • 2.1
      Origin and Transport of Gastric Bicarbonate
    • 2.2
      Contribution of Bicarbonate Leakage
    • 2.3
      Duodenal Mucosal Transport of Bicarbonate
    • 2.4
      Gradient in Secretion Along the Duodenum
    • 2.5
      Biochemical Basis for Duodenal Bicarbonate Secretion
  • 3
    Physiological Control of Gastroduodenal Bicarbonate Secretion
    • 3.1
      Humoral Control
    • 3.2
      Neural Influence
    • 3.3
      Control by Mucosal Endogenous Prostaglandins
    • 3.4
      Relation to Gastric Acid Secretion and Blood Flow
  • 4
    Pharmacological Modulation
    • 4.1
      Inhibitors of Gastric Alkaline Secretion
    • 4.2
      Stimulation of Gastric Alkaline Secretion by Prostaglandins
    • 4.3
      Duodenal Mucosal Alkaline Secretion and cAMP
    • 4.4
      Stimulation of Duodenal Secretion by Prostaglandins
    • 4.5
      Other Drugs Affecting Duodenal Alkaline Secretion
  • 5
    Protective Role of Bicarbonate
    • 5.1
      Surface pH Gradient
    • 5.2
      Possible Therapeutic Implications
  • 6
    Summary and Perspectives