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Hepatic Transport of Organic Solutes

Handbook of Physiology, The Gastrointestinal System, Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion

  1. E. L. Forker

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060334

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Forker, E. L. 2011. Hepatic Transport of Organic Solutes. Comprehensive Physiology. 693–716.

Author Information

  1. Departments of Medicine and Physiology, University of Missouri School of Medicine, Columbia, Missouri

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Functional Anatomy
    • 1.1
      Vascular Organization of Hepatic Parenchyma
    • 1.2
      Structural Adaptations for Efficient Solute Exchange Between Blood and Tissue
    • 1.3
      Liver Cell Plates, Canaliculi, and Tight Junctions
    • 1.4
      Intra-Acinar Heterogeneity
  • 2
    Experimental Methods
  • 3
    Transport Mechanisms
    • 3.1
      Classification
    • 3.2
      Carrier-Mediated Transport
    • 3.3
      Compartmentation of Solutes Inside Cell and in Bile
    • 3.4
      Effect of Choleresis on Canalicular Anion Transport
  • 4
    Mathematical Modeling
    • 4.1
      Steady-State Input-Output Relations
    • 4.2
      Distribution of Flow to Multiple Sinusoids
    • 4.3
      Estimating Uptake, Efflux, and Removal Separately
  • 5
    Uptake of Albumin-Bound Organic Anions
    • 5.1
      Historical Perspective
    • 5.2
      Dissociation-Mediating Sites on the Cell Surface?
    • 5.3
      Specificity
  • 6
    Transport of Specific Solute Classes
    • 6.1
      Bile Acids
    • 6.2
      Long-Chain Fatty Acids
    • 6.3
      Other Organic Anions
    • 6.4
      Amino Acids
    • 6.5
      Organic Cations
    • 6.6
      Neutral Compounds
    • 6.7
      Intracellular Binding Proteins
    • 6.8
      Putative Membrane Carriers
  • 7
    Conclusion