Standard Article

Transport and Metabolism in the Hepatobiliary System

Handbook of Physiology, The Gastrointestinal System, Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion

  1. Dirk K. F. Meijer

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060335

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Meijer, D. K. F. 2011. Transport and Metabolism in the Hepatobiliary System. Comprehensive Physiology. 717–758.

Author Information

  1. Department of Pharmacology and Therapeutics, University Center of Pharmacy, University of Groningen, Groningen, The Netherlands, Groningen, The Netherlands

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Methodology
  • 2
    Factors Influencing Clearance of Drugs by The Liver
    • 2.1
      Chemical Structure
    • 2.2
      Protein Binding
    • 2.3
      Bile Flow
    • 2.4
      Adaptive Changes
    • 2.5
      Biotransformation, Detoxification, Toxification
    • 2.6
      Acinar Heterogeneity
  • 3
    Mechanisms Of Membrane Transport of Organic Compounds
    • 3.1
      General Considerations
    • 3.2
      Organic Anions
    • 3.3
      Organic Cations
    • 3.4
      Uncharged Compounds
  • 4
    Conclusion