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Biology Of Sodium-Absorbing Epithelial Cells: Dawning of a New Era

Handbook of Physiology, The Gastrointestinal System, Intestinal Absorption and Secretion

  1. Stanley G. Schultz1,
  2. Randall L. Hudson2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060402

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Schultz, S. G. and Hudson, R. L. 2011. Biology Of Sodium-Absorbing Epithelial Cells: Dawning of a New Era. Comprehensive Physiology. 45–81.

Author Information

  1. 1

    Department of Physiology and Cell Biology, University of Texas School of Medicine, Houston, Texas

  2. 2

    Present address of R. L. Hudson: Department of Physiology and Biophysics, University of Illinois School of Medicine, Chicago, IL

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    • 1.1
      Birth of Modern Era of Epitheliology
    • 1.2
      Extensions and Modifications of Original Koefoed-Johnsen—Ussing Model
    • 1.3
      Regulation of Intracellular Ion Composition and Volume
    • 1.4
  • 2
    Na+ Transport Pool
    • 2.1
      Intracellular Na+ Compartment
    • 2.2
      What is the Relation Between Cell Na+ Activity and Na+ Pump Rate?
  • 3
    Na+ Pump(S)
    • 3.1
    • 3.2
      Na+-ATPase: Is There a Second Na+ Pump?
    • 3.3
      Na+-HCO3 Cotransport Across Basolateral Membranes
    • 3.4
  • 4
    Basolateral Membrane K+ Conductance
    • 4.1
      Parallelism Between Rate of Transcellular Na+ Transport and Basolateral Membrane K+ Conductance
    • 4.2
      Physiological Utility of Parallelism Between Pump Rate and K+ Conductance of Basolateral Membrane
    • 4.3
      What Intracellular Signal(s) is Responsible for Parallelism Between Transcellular Na+ Transport, Pump Rate, and K+ Conductance of Basolateral Membranes?
    • 4.4
  • 5
    Volume Regulation
    • 5.1
      Are the Mechanisms Responsible for Pump-Leak Parallelism and Volume Regulatory Decrease Related?
    • 5.2
      Is Na+ Pump Rate Affected by Cell Swelling?
    • 5.3
      How do Cells “Recognize” an Increase in Volume?
    • 5.4
  • 6
    Regulation of Cell Ca2+
  • 7
    Summary: Toward A “New Biology” of Na+ -Absorbing Epithelial Cells