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Gastric Intrinsic Factor and Cobalamin Absorption

Handbook of Physiology, The Gastrointestinal System, Intestinal Absorption and Secretion

  1. Bellur Seetharam,
  2. David H. Alpers

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060420

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Seetharam, B. and Alpers, D. H. 2011. Gastric Intrinsic Factor and Cobalamin Absorption. Comprehensive Physiology. 437–461.

Author Information

  1. Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Types of Cobalamin
  • 2
    Dietary Sources and Requirements
  • 3
    Biological Reactions and Deficiency Manifestations
  • 4
    Cobalamin-Binding Proteins
    • 4.1
      Definition
    • 4.2
      Specifity of Structure and Binding
    • 4.3
      Site of Production, Synthesis, and Secretion
    • 4.4
      Structure, Function, and Congenital Abnormalities
  • 5
    Intestinal Absorption of Cobalamin
    • 5.1
      Gastric Phase
    • 5.2
      Intestinal Luminal Phase
    • 5.3
      Mucosal Phase
    • 5.4
      Studies on Ileal Receptor
    • 5.5
      Passive Absorption and Absorption in Neonatal Period
    • 5.6
      Uptake and Fate of Intrinsic Factor
    • 5.7
      Measurement of Cobalamin Absorption and Body Stores
  • 6
    Disorders of Cobalamin Absorption