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Protein Kinases and Phosphatases in Cellular Signaling

Handbook of Physiology, The Endocrine System, Cellular Endocrinology

  1. Karen L. Leach

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070110

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Leach, K. L. 2011. Protein Kinases and Phosphatases in Cellular Signaling. Comprehensive Physiology. 225–253.

Author Information

  1. Pharmacia & Upjohn, Inc., Cell Biology and Inflammation Research, Kalamazoo, Michigan

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Protein Kinase and Phosphatase Classification
  • 2
    Protein Kinase Structure
    • 2.1
      Serine/Threonine Kinases
    • 2.2
      Tyrosine Kinases
    • 2.3
      Dual-Specificity Kinases
  • 3
    Protein Phosphatase Structure
    • 3.1
      Serine/Threonine Phosphatases
    • 3.2
      Tyrosine Phosphatases
    • 3.3
      Dual-Specificity Phosphatases
  • 4
    Kinase and Phosphatase Regulation
    • 4.1
      Localization
    • 4.2
      Phosphorylation
    • 4.3
      Regulation via Autoinhibitory Domains
    • 4.4
      Substrate Specificity
  • 5
    Protein Kinase C
    • 5.1
      Structure
    • 5.2
      Isozyme Specificity
    • 5.3
      Isozymes in Cellular Function
  • 6
    Calcineurin
    • 6.1
      Enzyme Structure
    • 6.2
      Isoforms
    • 6.3
      Substrate Specificity
    • 6.4
      Endogenous Substrates
    • 6.5
      T-Cell Activation
    • 6.6
      Nuclear Factor of Activated T Cells as a Substrate
    • 6.7
      FK506 and Cyclosporin A as Probes of Calcineurin Action
  • 7
    Role of CDC25 in Cell-Cycle Progression
    • 7.1
      Overview of Cell-Cycle Proteins
    • 7.2
      Cdc2
    • 7.3
      Cdc25
  • 8
    Conclusions