Standard Article

The Roles of Cytochromes P-450 in the Regulation of Steroidogenesis

Handbook of Physiology, The Endocrine System, Cellular Endocrinology

  1. Peter F. Hall

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070116

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Hall, P. F. 2011. The Roles of Cytochromes P-450 in the Regulation of Steroidogenesis. Comprehensive Physiology. 413–437.

Author Information

  1. Prince of Wales Hospital, Randwick, Department of Endocrinology and Metabolism, Division of Medicine, New South Wales, Australia

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Properties of Cytochromes P-450
    • 1.1
      Chemical Properties
    • 1.2
      Spectral Properties
    • 1.3
      The P-450 Cycle
    • 1.4
      The Mechanism of P-450 Enzyme Activity
    • 1.5
      Reduction of Cytochrome P-450
  • 2
    Synthesis of Steroid Hormones
    • 2.1
      Nomenclature
    • 2.2
      Pathways to Steroid Hormones
  • 3
    Individual Cytochromes P-450
    • 3.1
      C27 Side-Chain Cleavage P-450
    • 3.2
      C21 Side-Chain Cleavage P-450 (Hydroxylase/Lyase)
  • 4
    C21 Hydroxylase
  • 5
    11β-Hydroxylase and Aldehyde Synthetase
  • 6
    Aromatase
  • 7
    The Role of Membranes in the Actions of Cytochromes P-450
    • 7.1
      The Steroidogenic Inner Mitochondrial Membrane
    • 7.2
      The Steroidogenic Endoplasmic Reticulum
  • 8
    Molecular Biology of Cytochromes P-450
    • 8.1
      Cytochrome P-450c27scc (CYPII)
    • 8.2
      Cytochrome P-450 C21scc (17α-hydroxylase) (CYP17)
    • 8.3
      Cytochrome P-450 21-Hydroxylase (CYP21)
    • 8.4
      Cytochrome P-450 11β-Hydroxylase (CYP11)
    • 8.5
      Aromatase (CYP19)