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Insulin Gene Transcription: Factors Involved in Cell Type–Specific and Glucose-Regulated Expression in Islet β Cells are Also Essential During Pancreatic Development

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. Roland Stein

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070202

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Stein, R. 2011. Insulin Gene Transcription: Factors Involved in Cell Type–Specific and Glucose-Regulated Expression in Islet β Cells are Also Essential During Pancreatic Development. Comprehensive Physiology. 25–47.

Author Information

  1. Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Insulin Gene Expression
  • 2
    Principal Factors Regulating Insulin Gene Transcription
    • 2.1
      C2 Element
    • 2.2
      Z-Element Region
    • 2.3
      A Elements
    • 2.4
      C1/RIPE3b1 Element
    • 2.5
      E Element
    • 2.6
      Other Key Pancreatic Cell Transcriptional Regulators
  • 3
    Targeted Disruption of Insulin Transcriptional Activators
    • 3.1
      PDX-1 in Pancreatic Islet and Exocrine Cell Development
    • 3.2
      Isl-1, Pax-6, Pax-4, and BETA2/NeuroD in Islet Endocrine Cell Development
    • 3.3
      Other Transcription Factors Necessary for Islet Cell Development
  • 4
    Factors Regulating pdx-1 Gene Transcription
  • 5
    New Perspectives
  • 6
    Summary