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Substrate Control of Insulin Release

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. Christopher B. Newgard1,
  2. Franz M. Matschinsky2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070205

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Newgard, C. B. and Matschinsky, F. M. 2011. Substrate Control of Insulin Release. Comprehensive Physiology. 125–151.

Author Information

  1. 1

    Gifford Laboratories for Diabetes Research and Departments of Biochemistry and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

  2. 2

    Diabetes Research Center and Department of Biochemistry and Biophysics, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Cellular Architecture of Pancreatic Islets
  • 2
    General Aspects of Nutrient Sensing
  • 3
    The Glucose-Sensing System: A Basic Model
  • 4
    Adenine Nucleotides and the Adenosine Triphosphate–Sensitive Potassium Channel
  • 5
    Regulation of Glucose Metabolism in Islet β Cells
  • 6
    Molecular Manipulations of Glucose-Phosphorylating Activity in Islet Cells
  • 7
    Similarities and Differences in the Metabolic Environment of β Cells and Hepatocytes
  • 8
    Role of Lipids in Regulation of Insulin Secretion
  • 9
    Fundamentals of Amino Acid-Stimulated Insulin Release
  • 10
    Mitochondria as Metabolic Signal Generators of Fuel-Stimulated β Cells
  • 11