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Insulin Degradation and Insulin-Degrading Enzyme

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. William C. Duckworth1,
  2. Frederick G. Hamel2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070207

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Duckworth, W. C. and Hamel, F. G. 2011. Insulin Degradation and Insulin-Degrading Enzyme. Comprehensive Physiology. 177–194.

Author Information

  1. 1

    Diabetes Research, Veterans Affairs Medical Center, and Arizona State University, Phoenix, Arizona

  2. 2

    Departments of Medicine and Pharmacology, University of Nebraska Medical School, and Veterans Affairs Medical Center, Omaha, Nebraska

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Historical Perspective
  • 2
    Current Model of Insulin Degradation
    • 2.1
      Insulin Clearance
    • 2.2
      Liver
    • 2.3
      Kidney
    • 2.4
      Orfier Tissues
    • 2.5
      General Cellular Processes
    • 2.6
      Enzymatic Mechanisms for Cellular Metabolism of Insulin
  • 3
    Insulin-Degrading Enzyme
    • 3.1
      General Characteristics
    • 3.2
      Molecular Characteristics
    • 3.3
      Cellular Characteristics
  • 4
    Intracellular Insulin and Insulin Action
  • 5
    Conclusions and Future Prospects