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Glucagon and Glucagon-like Peptide Production and Degradation

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. Timothy J. Kieffer,
  2. Mehboob A. Hussain,
  3. Joel F. Habener

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070208

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Kieffer, T. J., Hussain, M. A. and Habener, J. F. 2011. Glucagon and Glucagon-like Peptide Production and Degradation. Comprehensive Physiology. 197–265.

Author Information

  1. Department of Medicine, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    History
    • 1.1
      Glucagon
    • 1.2
      Glucagon-like Peptides
  • 2
    The Glucagon Superfamily of Peptide Hormones
  • 3
    Tissue Distribution of Proglucagon Expression
    • 3.1
      Pancreas
    • 3.2
      Intestine
    • 3.3
      Brain
  • 4
    Proglucagon Biosynthesis
    • 4.1
      Organization and Structure of the Proglucagon Gene
    • 4.2
      Regulation of Glucagon Gene Expression
    • 4.3
      Posttranslational Processing of Proglucagon
    • 4.4
      Chemistry and Structure
  • 5
    Regulation of Glucagon Secretion
    • 5.1
      Overview
    • 5.2
      Intracellular Signals
    • 5.3
      Nutrients
    • 5.4
      Endocrine/Paracrine
    • 5.5
      Neural
    • 5.6
      Pulsatility
  • 6
    Regulation of Glucagon-like Peptide-1 Secretion
    • 6.1
      Overview
    • 6.2
      Intracellular Signals
    • 6.3
      Nutrients
    • 6.4
      Endocrine
    • 6.5
      Neural
  • 7
    Metabolism and Degradation
    • 7.1
      Overview
    • 7.2
      Renal Clearance
    • 7.3
      Hepatic Clearance
    • 7.4
      Degradation in the Circulation
    • 7.5
      Biologically Active Fragments
  • 8
    Physiological Actions
    • 8.1
      Glucagon
    • 8.2
      Glucagon-like Peptide-1
    • 8.3
      Glucagon-like Peptide-2
  • 9
    Mechanisms of Action
    • 9.1
      Glucagon
    • 9.2
      Glucagon-like Peptide-1
    • 9.3
      Glucagon-like Peptide-2
  • 10
    Human Disease
    • 10.1
      Glucagon
    • 10.2
      Glucagon-like Peptide-1
    • 10.3
      Glucagon-like Peptide-2