Standard Article

Molecular Aspects of Insulin Signaling

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. Renee Emkey,
  2. C. Ronald Kahn

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070212

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Emkey, R. and Kahn, C. R. 2011. Molecular Aspects of Insulin Signaling. Comprehensive Physiology. 413–433.

Author Information

  1. Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    The Insulin Receptor
  • 2
    Insulin Receptor Substrate 1
  • 3
    Role of Insulin Receptor Substrate 1 Sequence Polymorphisms in Humans and the Pathophysiology of Diabetes
  • 4
    Growing Family of Insulin Receptor Substrates
  • 5
    Complementary and Alternative Pathways in Insulin Signaling
  • 6
    A Polygenic Model of Non-Insulin-Dependent Diabetes Mellitus
  • 7
    Differential Subcellular Localization of Insulin Receptor Substrates 1 and 2
  • 8
    Insulin-Stimulated Insulin Receptor Substrate Interactions
    • 8.1
      Src Homology-2 Domain-Mediated Interactions
    • 8.2
      Non-Src Homology-2 Domain-Mediated Interactions
  • 9
    Serine/Threonine Protein Kinases and the Final Biological Effects of Insulin
  • 10
    Differential Regulation of Insulin Receptor Substrates 1 and 2 and Phosphatidylinositol-3-Kinase
  • 11
    Linking Early Steps in Insulin Action to Late Postreceptor Events
    • 11.1
      Insulin Stimulation of Glucose Transport
    • 11.2
      Coupling of Insulin Action to the Nucleus of the Cell
  • 12
    Cross-Talk Between the Insulin-Signaling Network and Other Hormonal Response Pathways
  • 13
    Future Perspectives