Standard Article

Regulation of Ketogenesis in Liver

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. Victor A. Zammit

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070221

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Zammit, V. A. 2011. Regulation of Ketogenesis in Liver. Comprehensive Physiology. 659–673.

Author Information

  1. Hannah Research Institute, Ayr, United Kingdom

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Roles of Insulin and Glucagon in Substrate Supply for Hepatic Ketogenesis
  • 2
    Effects of Ketones on the Endocrine Pancreas and Adipose Tissue
  • 3
    Intrahepatic Partitioning of Fatty Acids Between Oxidation and Esterification
    • 3.1
      Pancreatic Hormone Effects on Enzyme Substrate Availability
    • 3.2
      Expression of Enzyme Activity
    • 3.3
      Role of Malonyl CoA
    • 3.4
      Role of Carnitine Palmitoyltransferase I Membrane Topology and Membrane-Protein Interactions
    • 3.5
      Control of Carnitine Palmitoyltransferase I over Ketogenesis: Effects of Altered Insulin Status
    • 3.6
      In Vivo Monitoring of Hepatic Acyl-CoA Partitioning
  • 4
    Intramitochondrial Regulation of Ketogenesis
    • 4.1
      Modulation of Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Activity
    • 4.2
      Examples of Physiological Conditions Involving Pancreatic Hormone Regulation of Ketogenesis
  • 5
    General Comments