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Genetic Regulation of Glucose Metabolism

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. Calum Sutherland,
  2. Richard O'Brien,
  3. Daryl K. Granner

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070223

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Sutherland, C., O'Brien, R. and Granner, D. K. 2011. Genetic Regulation of Glucose Metabolism. Comprehensive Physiology. 707–732.

Author Information

  1. Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Glucagon and Insulin Action
    • 1.1
      Signaling from the Cell Membrane to the Nucleus
    • 1.2
      DNA Elements and Their Binding Proteins
  • 2
    Genetic Regulation of the Hepatic Gluconeogenic Enzymes
    • 2.1
      Glucose-6-Phosphatase
    • 2.2
      Fructose-1,6-Bisphosphatase
    • 2.3
      Phosphoenolpyruvate Carboxykinase
  • 3
    Genetic Regulation of the Hepatic Glycolytic Enzymes
    • 3.1
      Glucokinase
    • 3.2
      6-Phosphofructo-1-Kinase
    • 3.3
      Pyruvate Kinase
    • 3.4
      6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase
  • 4
    Genetic Regulation of Other Proteins Involved in Glucose Metabolism
    • 4.1
      Glyceraldehyde-3-Phosphate Dehydrogenase
    • 4.2
      Tyrosine Aminotransferase
    • 4.3
      GLUT-1 Glucose Transporter
    • 4.4
      Hexokinase II
  • 5
    Genetic Regulation of Lipogenic Enzymes
    • 5.1
      Acetyl-CoA Carboxylase
    • 5.2
      Fatty Acid Synthase
    • 5.3
      Malic Enzyme
  • 6
    Conclusions and Perspectives