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The Aging Pancreas: Effects of Aging on Insulin Secretion and Action

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. William J. Evans1,
  2. Peter A. Farrell2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070232

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Evans, W. J. and Farrell, P. A. 2011. The Aging Pancreas: Effects of Aging on Insulin Secretion and Action. Comprehensive Physiology. 969–998.

Author Information

  1. 1

    Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas

  2. 2

    Noll Physiological Research Center, Pennsylvania State University, University Park, Pennsylvania

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Age and Body Composition
  • 2
    Association of Age to Fasting Glucose and Insulin
  • 3
    Insulin Action (Animal Studies)
    • 3.1
      Maturation and Glucose Transport
    • 3.2
      GLUT-4 and Phosphatidylinositol 3-Kinase
  • 4
    Insulin Action (Human Studies)
    • 4.1
      Abdominal Obesity and Free Fatty Acids
    • 4.2
      Blood Flow
    • 4.3
      Physical Activity
    • 4.4
      Effects of Diet
  • 5
    Insulin Secretion
    • 5.1
      Pancreatic Morphology
    • 5.2
      Insulin Secretion and Free Fatty Acids
    • 5.3
      Relationship with Circulating Glucose and Age
    • 5.4
      Glucose Clamp Studies
  • 6
    Insulin Clearance
  • 7
    Insulin Secretion at The Organ, Islet and Single-Cell Level
    • 7.1
      Insulin Secretion In Situ
    • 7.2
      Insulin Secretion from Isolated Islets of Langerhans
    • 7.3
      Insulin Secretion from Single Beta Cells
    • 7.4
      Insulin Genes
    • 7.5
      Single Cell Secretion
  • 8
    Glucagon
  • 9
    Pancreatic Polypeptide
  • 10
    Amylin
  • 11
    Somatostatin
  • 12
    Conclusion