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Type I Diabetes Mellitus (Insulin-Dependent Diabetes Mellitus)

Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism

  1. Robert A. Rizza,
  2. Michael D. Jensen,
  3. K. Sreekumaran Nair

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070236

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Rizza, R. A., Jensen, M. D. and Nair, K. S. 2011. Type I Diabetes Mellitus (Insulin-Dependent Diabetes Mellitus). Comprehensive Physiology. 1093–1114.

Author Information

  1. Division of Endocrinology, Mayo Clinic, Rochester, Minnesota

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Pathogenesis of Type I Diabetes
  • 2
    Effect of Type I Diabetes on Carbohydrate Metabolism
    • 2.1
      Insulin Secretion and Action
    • 2.2
      Postabsorptive and Postprandial Carbohydrate Metabolism
  • 3
    Effects of Type I Diabetes and Its Treatment on Fatty Acid Metabolism
    • 3.1
      Adipose Tissue
    • 3.2
      Postabsorptive FFA Metabolism
    • 3.3
      Postprandial FFA Availability
    • 3.4
      Effects of Exercise on Adipose Tissue Lipolysis
    • 3.5
      Regulation of Lipolysis During Hypoglycemia
  • 4
    Effects Of Type I Diabetes on Protein Metabolism
    • 4.1
      Regulation of Body Protein Mass, Amino Acid Levels and Nitrogen Balance
    • 4.2
      Effect of Insulin on Protein Balance and Interaction of Insulin with Other Hormones and Substrates
    • 4.3
      Effects of Insulin on Whole-Body Protein Dynamics
    • 4.4
      Effect of Insulin on Amino Acid Transamination
    • 4.5
      Effect of Insulin on Regional Protein Dynamics
    • 4.6
      Effect of Insulin on the Synthesis Rates of Specific Proteins
    • 4.7
      Impact of Type I Diabetes on Protein Metabolism