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Parathyroid Hormone and Polyhormones: Production and Export

Handbook of Physiology, The Endocrine System, Endocrine Regulation of Water and Electrolyte Balance

  1. Ruben Diaz1,
  2. Ghada El-Hajj Fuleihan1,
  3. Edward M. Brown2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070316

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Diaz, R., Fuleihan, G. E.-H. and Brown, E. M. 2011. Parathyroid Hormone and Polyhormones: Production and Export. Comprehensive Physiology. 605–662.

Author Information

  1. 1

    Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts

  2. 2

    Endocrine Division, Children's Hospital, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Role of Extracellular Calcium–Sensing and Extracellular Calcium–Regulated Parathyroid Hormone Secretion in Mineral ion Homeostasis
  • 2
    The G Protein–Coupled, Extracellular Calcium–Sensing Receptor
    • 2.1
      Structure and Function
    • 2.2
      Inherited Diseases Resulting from Receptor Mutations
    • 2.3
      Mice with Targeted Disruption of the Receptor
    • 2.4
      Are There Additional Receptors or Other Ion-Sensing Receptors?
  • 3
    Anatomy and Physiology of the Parathyroid Cell
    • 3.1
      Morphology
    • 3.2
      Secretory Pathway
  • 4
    Physiological Control of Parathyroid Hormone Secretion by Extracellular Calcium and Other Factors
    • 4.1
      Acute Regulation
    • 4.2
      Additional Ionic Agonists Regulating Parathyroid Hormone Secretion via the Extracellular Calcium-Sensing Receptor
    • 4.3
      Other Ions Modulating Parathyroid Hormone secretion
    • 4.4
      Rapid Actions of Vitamin D on Parathyroid Cells
    • 4.5
      Regulation of Parathyroid Hormone Secretion by Catecholamines and Other Biogenic Amines
    • 4.6
      Regulation of Parathyroid Hormone Secretion by Lipid Metabolites
    • 4.7
      Regulation of Parathyroid Hormone Secretion by Peptides and Peptide Hormones
    • 4.8
      Miscellaneous Factors Regulating Parathyroid Hormone Secretion
    • 4.9
      Mechanisms Underlying the Acute Regulation of Parathyroid Hormone Secretion by Extracellular Calcium
  • 5
    Regulation of Intracellular Degradation of Parathyroid Hormone
  • 6
    Regulation of Parathyroid Hormone Gene Expression
    • 6.1
      Chromosomal Localization and Organization of the Parathyroid Hormone Gene
    • 6.2
      Effects of Extracellular Calcium
    • 6.3
      Effects of Extracellular Phosphate
    • 6.4
      Effects of Vitamin D Metabolites
    • 6.5
      Parathyroid Hormone Regulation of Gene Expression by Steroids and Other Hormones
    • 6.6
      Regulation of Parathyroid Hormone Gene Expression by Agents that Increase Intracellular Cyclic Adenosine Monophosphate
    • 6.7
      Regulation of Overall Biosynthetic Activity of the Parathyroid Cell
  • 7
    Regulation of Parathyroid Cellular Proliferation
    • 7.1
      Effects of Extracellular Calcium
    • 7.2
      Effects of Vitamin D Metabolites
    • 7.3
      Effect of Extracellular Phosphate
    • 7.4
      Effect of Growth Factors
  • 8
    Circadian and Pulsatile Control of Parathyroid Hormone Secretion
    • 8.1
      Circadian Variation
    • 8.2
      Pulsatility
    • 8.3
      Alterations in Circadian Rhythm and Pulsatility in Patients with Abnormal Parathyroid Function
  • 9
    Secretion of Factors Other Than Parathyroid Hormone: Possible Autocrine/ Paracrine Regulation of Parathyroid Hormone Secretion
    • 9.1
      Evidence for Autocrine Control of Parathyroid Function
    • 9.2
      Secretion of Parathyroid Hormone–Related Protein
    • 9.3
      Secretion of Chromogranin A-Derived Peptides
    • 9.4
      Secretion of Other Peptides
    • 9.5
      Secretion of Prostaglandins