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Neurobiology of Interpreting and Responding to Stressful Events: Paradigmatic Role of the Hippocampus

Handbook of Physiology, The Endocrine System, Coping with the Environment: Neural and Endocrine Mechanisms

  1. Bruce S. McEwen

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070409

Comprehensive Physiology

Comprehensive Physiology

How to Cite

McEwen, B. S. 2011. Neurobiology of Interpreting and Responding to Stressful Events: Paradigmatic Role of the Hippocampus. Comprehensive Physiology. 155–178.

Author Information

  1. Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Physiological Stress Responses
    • 1.1
      What Systems Respond to Stressors?
    • 1.2
      Habituation and Sensitization
    • 1.3
      Psychosocial Stressors
  • 2
    Plasticity and Adaptation in the Central Nervous System: Hippocampus
    • 2.1
      Role of the Hippocampus in Behavioral and Neuroendocrine Adaptation
    • 2.2
      Plasticity of the Hippocampus
  • 3
    Hippocampal Neuronal Morphology is Altered by Hibernation, Chronic Stress, and Aging
    • 3.1
      Pharmacological Manipulations of Dendritic Atrophy
    • 3.2
      Mechanism of Dendritic Atrophy and Role of Adrenal Steroids
    • 3.3
      Hippocampal Neuronal Damage Resulting from Chronic Stress and Aging
    • 3.4
      Structural Changes in the Human Hippocampus
    • 3.5
      Stress Effects on Cognitive Performance in Rodents and Humans
    • 3.6
      Life-Long Implications of Stressful Experiences
  • 4
    The Price of Adaptation: Allostasis and Allostatic Load
    • 4.1
      Definitions
    • 4.2
      Anticipation and Behavior in Allostatic Load
    • 4.3
      Four Types of Allostatic Load
    • 4.4
      Individuals versus Groups
    • 4.5
      Measurement of Allostatic Load
  • 5
    Conclusions