Standard Article

Mechanisms of Glucocorticoid Actions in Stress and Brain Aging

Handbook of Physiology, The Endocrine System, Coping with the Environment: Neural and Endocrine Mechanisms

  1. Nada M. Porter1,
  2. James P. Herman2,
  3. Philip W. Landfield3

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070414

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Porter, N. M., Herman, J. P. and Landfield, P. W. 2011. Mechanisms of Glucocorticoid Actions in Stress and Brain Aging. Comprehensive Physiology. 293–309.

Author Information

  1. 1

    Department of Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky

  2. 2

    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky

  3. 3

    Department of Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Glucocorticoids in Relation to Stress and Aging
    • 1.1
      Association of Glucocorticoids with Brain Aging
    • 1.2
      Experimental Interventions in Glucocorticoid Actions
    • 1.3
      Caloric Restriction
    • 1.4
      Possible Trophic Actions of Glucocorticoids
    • 1.5
      Studies in Humans
  • 2
    Modulation of the Adrenal Axis
    • 2.1
      Basic Regulatory Mechanisms: Systemic, Receptor, and Genomic Levels
    • 2.2
      Adrenocorticoid Receptors: Effects of Stress and Aging
  • 3
    Cellular Mechanisms of Neuronal Toxicity of Glucocorticoids
    • 3.1
      Excitotoxicity and Glucose Metabolism
    • 3.2
      Ion Channels and Calcium Homeostasis
  • 4
    Conclusion