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The Growth Hormone Secretory Pattern and Statural Growth

Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

  1. Iain C. A. F. Robinson1,
  2. Peter C. Hindmarsh2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070512

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Robinson, I. C. A. F. and Hindmarsh, P. C. 2011. The Growth Hormone Secretory Pattern and Statural Growth. Comprehensive Physiology. 329–395.

Author Information

  1. 1

    Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London, United Kingdom

  2. 2

    Department of Paediatric Endocrinology, Cobbold Laboratories, The Middlesex Hospital, London, United Kingdom

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    How is the Growth Hormone Secretory Pattern Analyzed?
    • 1.1
      General Considerations in Pulse Analysis of Growth Hormone Secretion
    • 1.2
      Construction of Data Arrays or Hormone Profiles
    • 1.3
      Sampling Interval and Aliasing
    • 1.4
      Duration of Sampling
    • 1.5
      Discrete or Integrated Samples
    • 1.6
      Assays and Noise
    • 1.7
      Basic Evaluation
    • 1.8
      Stationarization
    • 1.9
      Analysis of Profiles
    • 1.10
      Time Series Analysis
    • 1.11
      Deconvolution Analysis
    • 1.12
      Baseline Occupancy
    • 1.13
      Chaos
    • 1.14
      Neural Networks
  • 2
    Characterization of Growth Hormone Secretory Patterns
    • 2.1
      Ontogeny of Episodic Growth Hormone Secretion
    • 2.2
      Growth Hormone Secretory Patterns in the Prepubertal Period
    • 2.3
      Puberty and Effects of Gonadal Steroids on the Growth Hormone Secretory Pattern
    • 2.4
      Growth Hormone Secretory Patterns in Adulthood
    • 2.5
      Other Endocrine Inputs Affecting Growth Hormone Secretory Patterns
    • 2.6
      Extrinsic Factors Affecting Growth Hormone Pulsatility
  • 3
    How Does the Growth Hormone Secretory Pattern Reflect the Episodic Nature of Hypothalamic Control Mechanisms?
    • 3.1
      Growth Hormone–Releasing Hormone and Somatostatin Interactions Generate Growth Hormone Pulsatility
    • 3.2
      Other Growth Hormone Secretogogues
    • 3.3
      Growth Hormone Feedback Effects on Endogenous Growth Hormone Pulsatility
  • 4
    How is The Growth Hormone Secretory Signal Modified in its Passage from the Pituitary to the Peripheral Target Tissues?
    • 4.1
      How Are Growth Hormone Patterns Modified by Interactions with Growth Hormone Binding Proteins?
  • 5
    How are the Temporal Elements of the Growth Hormone Signal Detected and Interpreted by the Target Tissues?
    • 5.1
      Pattern-Dependent Growth Hormone Responses
    • 5.2
      Growth Hormone Patterns and Insulin-Like Growth Factor I Generation
  • 6
    What is the Significance of the Growth Hormone Secretory Pattern for Statural Growth?
    • 6.1
      Animal Studies
    • 6.2
      Human Studies
    • 6.3
      Indirect Manipulation of Growth Hormone Secretory Pattern
  • 7
    Summary