Standard Article

The Growth Hormone Receptor

Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

  1. Michael J. Waters

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070513

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Waters, M. J. 2011. The Growth Hormone Receptor. Comprehensive Physiology. 397–444.

Author Information

  1. Department of Physiology and Pharmacology, The University of Queensland, St. Lucia, Queensland, Australia

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Cloning of the Receptor
  • 2
    The Hematopoietic Cytokine Receptor Family
  • 3
    The Crystal Structure of the Growth Hormone Receptor and its Complex with the Hormone
    • 3.1
      Stoichiometry
    • 3.2
      Domain Structure
    • 3.3
      Binding to the Hormone
    • 3.4
      Comparison with the Prolactin Receptor
  • 4
    Structure of Growth Hormone and its Variants
    • 4.1
      Structural and Functional Studies on Human Growth Hormone
    • 4.2
      Nature of the Binding Specificity: Recruitment of Other Hormones
    • 4.3
      Improving the Binding Affinity
    • 4.4
      Binding to the Rabbit Growth Hormone Receptor
    • 4.5
      Determinants of Primate Specificity
  • 5
    Mechanisms for Generating the Biological Signals
    • 5.1
      Requirement for Dimerization
    • 5.2
      Apparent Exceptions to the Dimerization Requirement
    • 5.3
      Is Dimerization Sufficient? The Question of Conformational Change
  • 6
    The Growth Hormone Receptor Gene and the Syndrome of Growth Hormone Insensitivity
    • 6.1
      Structure of the Gene: Alternate Splicing
    • 6.2
      Primary Growth Hormone Insensitivity in Humans: Laron Dwarfism
  • 7
    The Growth Hormone-Binding Protein
    • 7.1
      Early Studies
    • 7.2
      The Modern Era
    • 7.3
      Identity of the Growth Hormone–Binding Protein
    • 7.4
      Mode of Release of the Growth Hormone–Binding Protein
    • 7.5
      Functional Aspects of Growth Hormone–Binding Proteins
    • 7.6
      Utility of Serum Growth Hormone–Binding Protein as a Measure of Growth Hormone Receptor Expression
    • 7.7
      Physiological Considerations: Relation to Growth Potential
    • 7.8
      Methods of Measuring Growth Hormone–Binding Protein Status
    • 7.9
      Regulation of Growth Hormone–Binding Protein
  • 8
    Receptor Regulation
    • 8.1
      The Receptor Life Cycle
    • 8.2
      Short-Term Processes: Downregulation
    • 8.3
      Long-Term Regulation: Induction of Receptor Message
    • 8.4
      Ontogeny
    • 8.5
      Sex and Pregnancy
    • 8.6
      Growth Hormone
    • 8.7
      Steroids
    • 8.8
      Other Factors
  • 9
    Receptor Localization
  • 10
    Conclusion