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The Somatomedin Hypothesis of Growth Hormone Action

Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

  1. Raymond L. Hintz

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070515

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Hintz, R. L. 2011. The Somatomedin Hypothesis of Growth Hormone Action. Comprehensive Physiology. 481–499.

Author Information

  1. Department of Pediatrics, Stanford University, Stanford, California

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Early Studies on the Mechanism of Growth Hormone Action
    • 1.1
      The Sulfation Factor Hypothesis
  • 2
    Characterization of Somatomedin Biological Activity in Serum
    • 2.1
      Stimulation of Differentiated Cell Functions
    • 2.2
      Increases in DNA, RNA, and Protein Synthesis
    • 2.3
      Synthesis and Control
    • 2.4
      Mechanisms of Action
    • 2.5
      Assays and Serum Levels of Somatomedin
  • 3
    Purification of Somatomedin from Serum
    • 3.1
      Biochemical Characterization
    • 3.2
      The Isolation and Sequencing of Nonsuppressible Insulin-Like Activity-S Peptides and the Insulin-Like Growth Factor Terminology
    • 3.3
      Relationship to Nonsuppressible Insulin-Like Activity-S and Multiplicating Stimulating Activity
  • 4
    Characterization of the Specific Somatomedin Peptides
    • 4.1
      Development of Specific Assays
    • 4.2
      Pathophysiology of Serum Levels
    • 4.3
      Somatomedin Receptor Sites
    • 4.4
      Somatomedin Binding Proteins
    • 4.5
      Metabolism and Feedback on Growth Hormone Secretion
    • 4.6
      Lessons from the RNA and DNA Structures of the Insulin-like Growth Factors
    • 4.7
      Paracrine Actions
    • 4.8
      The Dual Effector Hypothesis of Growth Hormone Action
  • 5
    Evidence that the Somatomedins are the Major Effectors of the Growth Actions of Growth Hormone
    • 5.1
      Indirect Evidence
    • 5.2
      Direct Evidence
  • 6
    Epilogue