Standard Article

Insulin-Like Growth Factors: Gene Structure and Regulation

Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

  1. Pauline Kay Lund

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070518

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Lund, P. K. 2011. Insulin-Like Growth Factors: Gene Structure and Regulation. Comprehensive Physiology. 537–571.

Author Information

  1. Departments of Physiology and Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Insulin-Like Growth Factor I
    • 1.1
      Insulin-Like Growth Factor I cDNAs and Encoded Precursors
    • 1.2
      Multiple Insulin-Like Growth Factor I mRNAs and Precursors in Mammals
    • 1.3
      Multiple Size Classes of Insulin-Like Growth Factor I mRNAs
    • 1.4
      Insulin-Like Growth Factor I Gene Structure
    • 1.5
      Functional Significance of Multiple Mammalian Insulin-Like Growth Factor I mRNAs and Precursors
    • 1.6
      Insulin-Like Growth Factor I mRNA Regulation
    • 1.7
      Structure And Regulation of the Insulin-Like Growth Factor I Promoters
  • 2
    Insulin-Like Growth Factor II
    • 2.1
      Insulin-Like Growth Factor II cDNAs and Encoded Precursors
    • 2.2
      Multiple Insulin-Like Growth Factor II mRNAs
    • 2.3
      Insulin-Like Growth Factor II Gene Structure
    • 2.4
      Insulin-Like Growth Factor II mRNA Regulation
    • 2.5
      Transcriptional Control of Insulin-Like Growth Factor II Synthesis
    • 2.6
      Post-Transcriptional Control of Insulin-Like Growth Factor II Synthesis
  • 3
    Manipulation of the Expression of Insulinlike Growth Factors I and II
    • 3.1
      Gain of Function Insulin-Like Growth Factor Transgenics
    • 3.2
      Loss of Function Insulin-Like Growth Factor Transgenics
    • 3.3
      Chimeric Genes and Insulin-Like Growth Factor Gene Regulation
  • 4
    Future Directions