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Insulin-Like Growth Factor Binding Proteins

Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

  1. David R. Clemmons

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070519

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Clemmons, D. R. 2011. Insulin-Like Growth Factor Binding Proteins. Comprehensive Physiology. 573–631.

Author Information

  1. Division of Endocrinology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Gene Structures
    • 1.1
      Insulin-Like Growth Factor Binding Protein 1
    • 1.2
      Insulin-Like Growth Factor Binding Protein 2
    • 1.3
      Insulin-Like Growth Factor Binding Protein 3
    • 1.4
      Insulin-Like Growth Factor Binding Protein 4
    • 1.5
      Insulin-Like Growth Factor Binding Protein 5
    • 1.6
      Insulin-Like Growth Factor Binding Protein 6
    • 1.7
      Acid Labile Subunit
  • 2
    Protein Structures
    • 2.1
      Insulin-Like Growth Factor Binding Protein 1
    • 2.2
      Insulin-Like Growth Factor Binding Protein 2
    • 2.3
      Insulin-Like Growth Factor Binding Protein 3
    • 2.4
      Insulin-Like Growth Factor Binding Protein 4
    • 2.5
      Insulin-Like Growth Factor Binding Protein 5
    • 2.6
      Insulin-Like Growth Factor Binding Protein 6
    • 2.7
      Insulin-Like Growth Factor Binding Protein-Related Proteins
  • 3
    Control of Gene Expression, Synthesis, and Secretion of Insulin-Like Growth Factor Binding Proteins by Cells and Tissues
    • 3.1
      Tissue Expression
    • 3.2
      Secretion by Cells In Vitro
  • 4
    Variables that Regulate Pericellular Abundanbce of Insulin-Like Growth Factor Binding Proteins
    • 4.1
      Proteolysis
    • 4.2
      Phosphorylation of Insulin-Like Growth Factor Binding Proteins
    • 4.3
      Binding to Cell Surfaces and to Extracellular Matrix
  • 5
    Regulation of Insulin-Like Growth Factor Actions in vitro and in vivo
    • 5.1
      Regulation of Half-Life
    • 5.2
      Modulation of Insulin-Like Growth Factor Actions
    • 5.3
      Specific Functions of Each Form of Binding Protein
    • 5.4
      A Unified Theory of the Mechanism of Action of Insulin-Like Growth Factor Binding Proteins in Connective Tissue Cells
    • 5.5
      Use of Insulin-Like Growth Factor Analogs
    • 5.6
      Related Proteins
  • 6
    Control of Insulin-Like Growth Factor Binding Protein Concentrations in Physiologic Fluids
    • 6.1
      Methodologic Considerations
    • 6.2
      Detection of Insulin-Like Growth Factor Binding Proteins in Physiologic Fluids Other than Blood
    • 6.3
      Regulation of Insulin-Like Growth Factor Binding Proteins in Serum
    • 6.4
      Regulation of Insulin-Like Growth Factor Binding Proteins by Hormones
  • 7
    Summary