Standard Article

Molecular Mechanisms of Insulin-like Growth Factor I Receptor Function: Implications for Normal Physiology and Pathological States

Handbook of Physiology, The Endocrine System, Hormonal Control of Growth

  1. Derek Leroith,
  2. Vicky A. Blakesley,
  3. Haim Werner

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp070520

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Leroith, D., Blakesley, V. A. and Werner, H. 2011. Molecular Mechanisms of Insulin-like Growth Factor I Receptor Function: Implications for Normal Physiology and Pathological States. Comprehensive Physiology. 633–662.

Author Information

  1. Diabetes Branch, National Institute of Diabetes, Digestive and Kidney, National Institutes of Health, Bethesda, Maryland

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Structural Aspects of Insulin-Like Growth Factor Receptors
    • 1.1
      Structure of the Insulin-Like Growth Factor I Receptor
    • 1.2
      Structure of the Insulin-Like Growth Factor I Receptor Gene and mRNA
    • 1.3
      The Regulatory Region of the Insulin-Like Growth Factor I Receptor Gene
  • 2
    Regulation of the Insulin-Like Growth Factor I Receptor Gene
    • 2.1
      Transcriptional Regulation
    • 2.2
      Regulation by Growth Factors
    • 2.3
      Repression of the Insulin-Like Growth Factor I Receptor by Tumor Suppressors
    • 2.4
      Developmental Regulation of the Insulin-Like Growth Factor I Receptor
  • 3
    Heterogeneity of the Insulin-Like Growth Factor I Receptor
    • 3.1
      Differences in Primary Structure
    • 3.2
      Additional Structural Heterogeneity
    • 3.3
      Hybrid Receptors
  • 4
    Function of the Insulin-Like Growth Factor I Receptor
    • 4.1
      The Receptor and Signaling
    • 4.2
      The Insulin-Like Growth Factor I Receptor and the Cell Cycle
    • 4.3
      The Insulin-Like Growth Factor I Receptor and Apoptosis
    • 4.4
      Function as Assessed by Loss of the Insulin-Like Growth Factor I Receptor: Studies of “Knock-out” Mice
    • 4.5
      Human Genetic Short Stature
  • 5
    The Role of Insulin-Like Growth Factor I Receptors in various Systems and Pathological States
    • 5.1
      Nervous System
    • 5.2
      Muscle
    • 5.3
      Reproductive System
    • 5.4
      Kidney
    • 5.5
      Immune System
    • 5.6
      Cancer
    • 5.7
      Effects of Insulin-Like Growth Factor I on Gene Expression
  • 6
    Conclusion