Standard Article

Renal Acidification: Integrated Tubular Responses

Handbook of Physiology, Renal Physiology

  1. Martin G. Cogan1,2,
  2. Albert H. Quan1,2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp080122

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Cogan, M. G. and Quan, A. H. 2011. Renal Acidification: Integrated Tubular Responses. Comprehensive Physiology. 970–1016.

Author Information

  1. 1

    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco

  2. 2

    Veterans Affairs Medical Center, San Francisco, California

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Normal Acidification by Nephron Segments
    • 1.1
      Overview of Mechanisms of Acidification
    • 1.2
      Rates of Acidification
    • 1.3
      pH Gradient
    • 1.4
      Physiological Roles of Normal Renal Acidification
  • 2
    Renal Response to Change in Glomerular Filtration Rate and Luminal Flow Rate
    • 2.1
      Bicarbonate Reabsorption
  • 3
    Renal Response to Decrease in Plasma Bicarbonate Concentration: Metabolic Acidosis
    • 3.1
      Bicarbonate Reabsorption
    • 3.2
      Ammonium Formation
    • 3.3
      Titratable Acid Formation
    • 3.4
      Integrated Nephron Response: Renal Net Acid Excretion
  • 4
    Renal Response to Increase in Plasma Bicarbonate Concentration: Metabolic Alkalosis
    • 4.1
      Exogenous Bicarbonate Administration without Extracellular Volume Contraction or Potassium Depletion
    • 4.2
      Bicarbonate Generation or Administration in the Setting of Chloride and Potassium Deficiencies
  • 5
    Renal Response to Alterations in Plasma inline image
    • 5.1
      Bicarbonate Reabsorption
    • 5.2
      Ammonium and Titratable Acid Formation
    • 5.3
      Integrated Nephron Response: Bicarbonate Reabsorption and Net Acid Excretion by the Whole Kidney