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Molecular Mechanisms of Vasopressin Action in the Kidney

Handbook of Physiology, Renal Physiology

  1. Karl L. Skorecki1,
  2. Dennis Brown2,
  3. Louis Ercolani2,
  4. Dennis A. Ausiello2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp080226

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Skorecki, K. L., Brown, D., Ercolani, L. and Ausiello, D. A. 2011. Molecular Mechanisms of Vasopressin Action in the Kidney. Comprehensive Physiology. 1185–1218.

Author Information

  1. 1

    Membrane Biology Group, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

  2. 2

    Renal Unit, Massachusetts General Hospital, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Localization of Vasopressin Action in the Kidney
    • 1.1
    • 1.2
      Vasa Recta
    • 1.3
      Medullary Thick Ascending Limb
    • 1.4
      Collecting Duct
    • 1.5
      Renal Medullary Interstitium
  • 2
    Molecular Mechanisms of Vasopressin Receptor (V2) Activation of Adenylate Cyclase
    • 2.1
      General Characteristics of Adenylate Cyclase Activation
    • 2.2
      Development of a Model for Vasopressin Receptor Stimulation of Adenylate Cyclase in the Renal Epithelial Membrane
    • 2.3
      Modulation of the Vasopressin-Sensitive Adenylate Cyclase Response
  • 3
    Role of Water Channel Recycling and Cytoskeletal Changes in the Hydroosmotic Response to Vasopressin
    • 3.1
    • 3.2
      Cellular and Molecular Events at the Apical Plasma Membrane
    • 3.3
      Role of the Cytoskeleton in Vasopressin Action
    • 3.4
      Isolation and Identification of the “Water Channel”
    • 3.5
      Future Directions