Standard Article

Atrial Natriuretic Factor

Handbook of Physiology, Renal Physiology

  1. Steven A. Atlas,
  2. Thomas Maack

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp080233

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Atlas, S. A. and Maack, T. 2011. Atrial Natriuretic Factor. Comprehensive Physiology. 1577–1673.

Author Information

  1. Department of Medicine, Department of Physiology, and the Cardiovascular Center, Cornell University Medical College, New York, New York

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Brief Historical Notes
  • 2
    Initial Findings
  • 3
    Isolation and Chemical Characterization
    • 3.1
      Structure of Low-Molecular-Weight ANF Peptides
    • 3.2
      Isolation of High-Molecular-Weight Forms
    • 3.3
      Nomenclature
  • 4
    Biosynthesis and Localization of ANF
    • 4.1
      Structures of the ANF Precursor, Messenger RNA, and Gene
    • 4.2
      Regulation of Gene Expression in Atrium
    • 4.3
      Biosynthetic Processing in Atrium
    • 4.4
      Gene Expression and Biosynthesis in Extraatrial Tissues
    • 4.5
      Homology with Other Proteins
  • 5
    Control of ANF Release
    • 5.1
      Atrial Distention
    • 5.2
      Atrial Contraction Frequency
    • 5.3
      Autonomic Influences on ANF Release
    • 5.4
      Other Vasoactive Agents
    • 5.5
      Other Factors
  • 6
    Pharmacokinetics and Metabolism
    • 6.1
      Pharmacokinetic Parameters
    • 6.2
      Sites of ANF Extraction
    • 6.3
      Metabolites of ANF
    • 6.4
      Clearance Pathways
  • 7
    ANF Receptors and Second Messengers
    • 7.1
      Biochemical Characteristics of ANF Receptors
    • 7.2
      Second Messengers of ANF Receptors
    • 7.3
      The Clearance Function of C-ANF Receptors
  • 8
    Functional Effects of ANF
    • 8.1
      Renal Actions
    • 8.2
      Effects on the Renin–Angiotensin–Aldosterone System
    • 8.3
      Effects on Other Steroid Pathways
    • 8.4
      Effects on the Cardiovascular System
    • 8.5
      Central Nervous System Actions
  • 9
    Physiological Role of ANF
  • 10
    ANF in Pathological Conditions
    • 10.1
      Edematous Disorders
    • 10.2
      Renal Failure
    • 10.3
      Hypertensive Disorders
    • 10.4
      Preeclampsia
    • 10.5
      Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
    • 10.6
      Bartter's Syndrome
    • 10.7
      Other Disorders
  • 11
    Conclusions