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Renal Prostaglandins and Other Eicosanoids

Handbook of Physiology, Renal Physiology

  1. Kirk P. Conrad1,
  2. Michael J. Dunn2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp080235

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Conrad, K. P. and Dunn, M. J. 2011. Renal Prostaglandins and Other Eicosanoids. Comprehensive Physiology. 1707–1757.

Author Information

  1. 1

    Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire

  2. 2

    Departments of Medicine and Physiology-Biophysics, Case Western Reserve University, Cleveland, Ohio

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Biochemistry
    • 1.1
      Eicosanoid Synthesis
    • 1.2
      Eicosanoid Degradation
    • 1.3
      Lipoxygenase and Epoxygenase Derivatives of Arachidonic Acid
    • 1.4
      Sites of Renal Eicosanoid Synthesis
    • 1.5
      Mechanism of Peptide Hormone Stimulation of Eicosanoid Synthesis
    • 1.6
      Eicosanoid Receptors and Mechanism of Action of Eicosanoids
    • 1.7
      Prostaglandin Excretion and Secretion
  • 2
    Influence of Prostaglandins on Renal Blood Flow and Glomerular Filtration Rate
    • 2.1
      Administration of Prostaglandins and Their Precursors
    • 2.2
      Influence of Cyclooxygenase Inhibition on Renal Blood Flow and Glomerular Filtration
    • 2.3
      Role of Prostaglandins in Renal Autoregulation and Tubuloglomerular Feedback
    • 2.4
      Hormonal Stimulation of Renal Prostaglandin Synthesis
    • 2.5
      Peptide Hormones and Prostaglandin Interactions in the Control of Renal Blood Flow
    • 2.6
      Some Conditions in Which Prostaglandins Exert an Important Vasodilatory Action
    • 2.7
      Summary: Prostaglandins and Renal Hemodynamics
  • 3
    Prostaglandins and Renal Water Excretion
    • 3.1
      Capacity of Renal Prostaglandins to Modulate Water Excretion in the Presence of Vasopressin
    • 3.2
      Capacity of Renal Prostaglandins to Modulate Water Excretion When Vasopressin Is Absent or Severely Reduced
    • 3.3
      Vasopressin and Vasopressin Analogs Stimulate Prostaglandin Synthesis in the Kidney
    • 3.4
      Mechanisms by Which Prostaglandins Modulate Renal Water Excretion
    • 3.5
      Prostaglandin Antagonism of AVP-Stimulated Water Flow: A Physiologic Phenomenon Mediated through the cyclic-AMP System?
    • 3.6
      Summary: Prostaglandins and Renal Water Excretion
  • 4
    Staglandins and Sodium Excretion
    • 4.1
      Influence of Prostaglandins and Arachidonic Acid on Renal Sodium Excretion
    • 4.2
      Cyclooxygenase Inhibition and Renal Sodium Excretion
    • 4.3
      Effect of Sodium Intake on Renal Prostaglandin Synthesis and Excretion
    • 4.4
      Nephron Sites Where Prostaglandins Oppose Sodium Absorption
    • 4.5
      Summary: Prostaglandins and Sodium Excretion
  • 5
    Contribution of Prostaglandins to the Renal Release of Renin
    • 5.1
      Effects of Exogenous Prostaglandins and Arachidonic Acid on Renal Renin Release
    • 5.2
      Influence of Cyclooxygenase Inhibition on Renal Renin Release
    • 5.3
      Renin Release by the β-Adrenergic, Renal Baroreceptor, and Macula Densa Mechanisms: Role of Prostaglandins
    • 5.4
      Summary: Prostaglandins and Renin Release
  • 6
    Prostaglandins as Mediators of Erythropoietin Release
  • 7
    Effect of Prostaglandins on Tubular Transport of Calcium, Phosphate, and Magnesium, and on Renal Ammoniagenesis
    • 7.1
      Calcium
    • 7.2
      Phosphate
    • 7.3
      Magnesium
    • 7.4
      Renal Ammoniagenesis