Standard Article

Glucose Transport in the Renal Proximal Tubule

Handbook of Physiology, Renal Physiology

  1. Mel Silverman1,
  2. R. James Turner2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp080243

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Silverman, M. and Turner, R. J. 2011. Glucose Transport in the Renal Proximal Tubule. Comprehensive Physiology. 2017–2038.

Author Information

  1. 1

    Membrane Biology Group, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

  2. 2

    Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    General Characteristics
    • 1.1
      Glucose Handling by the Whole Kidney
    • 1.2
      Tubular Site of Reabsorption
    • 1.3
      d-Glucose Handling by the Intact Proximal Tubule
  • 2
    Current Understanding of the Mechanism of Glucose Reabsorption
    • 2.1
      Components of the Reabsorptive Mechanism
    • 2.2
      Energetics: Gradient Hypothesis
    • 2.3
      Na+ Dependence of Luminal versus Basolateral d-glucose Transport
    • 2.4
      Kinetics and Stoichiometry
    • 2.5
      Systematics of d-Glucose Reabsorption at the Cellular and Tubular Levels
    • 2.6
      Specificity Characteristics
  • 3
    Abnormalities of Glucose Reabsorption in the Renal Tubule
    • 3.1
      Renal Glycosuria
    • 3.2
      Fanconi's Syndrome
    • 3.3
      Specific Defects of d-Glucose Transport
  • 4
    Molecular Characterization of the Components of the d-Glucose Reabsorptive Pathway Across the Renal Proximal Tubule
    • 4.1
      The Luminal Na+-Dependent d-Glucose Carrier
    • 4.2
      The Basolateral Na+-Independent d-Glucose Carrier
  • 5
    Molecular Mechanism of Operation of the Na+-Dependent d-Glucose Transporter
  • 6
    Conclusion