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Renal Handling of Proteins and Polypeptides

Handbook of Physiology, Renal Physiology

  1. Thomas Maack

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp080244

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Maack, T. 2011. Renal Handling of Proteins and Polypeptides. Comprehensive Physiology. 2039–2082.

Author Information

  1. Departments of Physiology and Medicine, Cardiovascular Center, Cornell University Medical College, New York, New York

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Endocytosis
    • 1.1
      Fluid-Phase Endocytosis
    • 1.2
      Adsorptive Endocytosis
    • 1.3
      Nature and Functions of Endosomes
    • 1.4
      Lysosomal Hydrolysis of Absorbed Proteins
  • 2
    Renal Uptake and Extraction of Proteins and Polypeptides
    • 2.1
      Renal Accumulation of Administered Proteins
    • 2.2
      Nephron and Intracellular Localization of Protein Uptake
    • 2.3
      Renal Extraction and Turnover of Circulating Proteins
  • 3
    Filtration of Proteins
  • 4
    Tubular Absorption of Filtered Proteins
    • 4.1
      Effect of Inhibitors
    • 4.2
      Effect of Protein Charge
    • 4.3
      Competition for Tubular Uptake
    • 4.4
      Selective Constraint Model
    • 4.5
      Tubular Absorption of Albumin
    • 4.6
      Urinary Proteins and Proteinurias
  • 5
    Intracellular Transport and Hydrolysis of Absorbed Proteins
    • 5.1
      Vesicular Transport
    • 5.2
      Lysosomal Hydrolysis
    • 5.3
      Influence of Lysosomal pH on Renal Hydrolysis of Absorbed Proteins
    • 5.4
      Renal Hydrolysis of Absorbed Albumin
    • 5.5
      Deposition of Absorbed Protein within Renal Cells
  • 6
    Renal Handling of Specific Polypeptide Hormones
    • 6.1
      Insulin and Related Peptides
    • 6.2
      Glucagon and Related Peptides
    • 6.3
      Parathyroid Hormone
    • 6.4
      Atrial Natriuretic Factor
  • 7
    Conclusions