Standard Article

Effects of Diuretics on Renal Function

Handbook of Physiology, Renal Physiology

  1. Jules B. Puschett1,2,
  2. Joseph Winaver3

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp080250

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Puschett, J. B. and Winaver, J. 2011. Effects of Diuretics on Renal Function. Comprehensive Physiology. 2335–2406.

Author Information

  1. 1

    Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana

  2. 2

    Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh; and Presbyterian-University and Veterans Administration Hospitals, Pittsburgh, Pennsylvania

  3. 3

    Department of Physiology and Biophysics, Faculty of Medicine, and Rappaport Family Institute for Medical Research, Technion, Haifa, Israel

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Diuretic Effects on Renal Hemodynamics
    • 1.1
      Drugs That Primarily Alter Glomerular Function
    • 1.2
      Drugs That Primarily Alter Tubular Function
    • 1.3
      Diuretic Effects on Intrarenal Blood Flow Distribution
    • 1.4
      Diuretic Interactions with the Renin–Angiotensin-Aldosterone system
    • 1.5
      Diuretic Interactions with Prostaglandin Synthesis and with the Inhibition of Prostaglandin Synthetase
  • 2
    Nephron Sites of Action and Effects of Diuretics on Solute Excretion
    • 2.1
      Review and Comparison of Methodologies
    • 2.2
      Utility of the Clearance Technique for the Study of Diuretic Site and Mechanism of Action in Man
    • 2.3
      Diuretic Effects on the Excretion of Specific Solutes
  • 3
    Cellular and Molecular Actions of Diuretics
    • 3.1
      Carbonic Anhydrase Inhibitors
    • 3.2
      Loop Diuretics
    • 3.3
    • 3.4
      Mineralcorticoid Antagonists
    • 3.5