Standard Article

Effects of Ionizing Radiation on Mammalian Cells

Handbook of Physiology, Reactions to Environmental Agents

  1. John B. Little,
  2. Jerry R. Williams

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp090108

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Little, J. B. and Williams, J. R. 2011. Effects of Ionizing Radiation on Mammalian Cells. Comprehensive Physiology. 127–155.

Author Information

  1. Laboratory of Radiobiology, Department of Physiology, Harvard University School of Public Health, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Physical and Chemical Events
    • 1.1
      Development of Radiation Injury
    • 1.2
      The Target Theory
    • 1.3
      Direct and Indirect Effects, Radiation Chemistry
  • 2
    Effects on Cell Division
    • 2.1
      Division Delay
    • 2.2
      Mitotic Inhibition (Reproductive Failure)
    • 2.3
      Radiation Sensitivity in Different Phases of the Life Cycle
    • 2.4
      Chromosomal Damage
    • 2.5
      Interphase Death
    • 2.6
      Nonlethal Heritable Changes
    • 2.7
      Biological Variation in Radiation Sensitivity
    • 2.8
      Mechanisms
  • 3
    Modification of Radiation Effects
    • 3.1
      Physical Factors
    • 3.2
      Chemical Radiation Protection and Sensitization
    • 3.3
      Oxygen Effect
    • 3.4
      Intracellular Recovery Processes
    • 3.5
      Repair of Potentially Lethal Damage
    • 3.6
      Repair of Sublethal Damage (Split-Dose Recovery)
  • 4
    Molecular Repair Processes
    • 4.1
      Damage Observed in DNA
    • 4.2
      Cellular Repair Systems for DNA Damage
    • 4.3
      Repair Activities in Mammalian Cells
    • 4.4
      Correlation of DNA Repair with Biological Effects
  • 5
    Concluding Remarks
  • 6
    Addendum