Standard Article

Permeability of the Skin

Handbook of Physiology, Reactions to Environmental Agents

  1. Robert J. Scheuplein

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp090119

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Scheuplein, R. J. 2011. Permeability of the Skin. Comprehensive Physiology. 299–322.

Author Information

  1. Department of Dermatology, Harvard Medical School at the Massachusetts General Hospital, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Manifestations of Skin Permeability
  • 2
    Structure of the Skin
    • 2.1
      Relevant Structural Features of the Whole Skin
  • 3
    The Stratum Corneum
    • 3.1
      Regional Variations in Structure
  • 4
    Human Versus Other Mammalian Skin
  • 5
    Biophysics of Skin Permeability
    • 5.1
      Mathematical Analysis of Skin Permeability
    • 5.2
      Steady-State Permeability of Skin—Fick's Law
    • 5.3
      Appendageal Diffusion
    • 5.4
      Concentration Levels in the Skin
    • 5.5
      Regional Variations in Permeability
  • 6
    Effect of Solvents and Surfactants
    • 6.1
      Water
    • 6.2
      Aprotic Solvents
    • 6.3
      Surfactants
    • 6.4
      Organic Solvents