Standard Article

Formation of Reactive Metabolites of Foreign Compounds and their Covalent Binding to Cellular Constituents

Handbook of Physiology, Reactions to Environmental Agents

  1. James R. Gillette

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp090137

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Gillette, J. R. 2011. Formation of Reactive Metabolites of Foreign Compounds and their Covalent Binding to Cellular Constituents. Comprehensive Physiology. 577–589.

Author Information

  1. Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Theoretical Considerations
  • 2
    Examples
    • 2.1
      Acetaminophen
    • 2.2
      Bromobenzene
    • 2.3
      Furosemide
    • 2.4
      Isoniazid and Iproniazid
  • 3
    Conclusion