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Chemical Mechanism of Myosin-Catalyzed ATP Hydrolysis

Handbook of Physiology, Skeletal Muscle

  1. Martin R. Webb,
  2. David R. Trentham

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp100108

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Webb, M. R. and Trentham, D. R. 2011. Chemical Mechanism of Myosin-Catalyzed ATP Hydrolysis. Comprehensive Physiology. 237–255.

Author Information

  1. Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Kinetics of ATP Binding and Hydrolysis
  • 2
    Nature of ATP Hydrolysis Step
    • 2.1
      Oxygen Exchange
    • 2.2
      Oxygen Isotope Incorporation
    • 2.3
      Positional Isotope Exchange
    • 2.4
      Stereochemistry of Phosphoryl Group Transfer
    • 2.5
      Structure of Magnesium-Nucleotide Complexes
  • 3
    Perspectives on Mechanism and Function of ATP Hydrolysis in Muscle