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Conformational Changes and Molecular Dynamics of Myosin

Handbook of Physiology, Skeletal Muscle

  1. John Gergely1,
  2. John C. Seidel2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp100109

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Gergely, J. and Seidel, J. C. 2011. Conformational Changes and Molecular Dynamics of Myosin. Comprehensive Physiology. 257–274.

Author Information

  1. 1

    Department of Muscle Research, Boston Biomedical Research Institute; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts

  2. 2

    Departments of Neurology and Biological Chemistry, Harvard Medical School, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Myosin Structure
    • 1.1
      Subunits
    • 1.2
      Actin Interaction Site
  • 2
    Myosin Interaction with ATP and its Analogues
    • 2.1
      Conformational Changes
    • 2.2
      Ultraviolet Spectral Changes
    • 2.3
      Electron Paramagnetic Resonance Spectra
    • 2.4
      Relation to ATPase Mechanism
    • 2.5
      Rod Conformational Changes
  • 3
    Chemical Modification
    • 3.1
      Cysteine Residue Modification
    • 3.2
      Lysine Modification
  • 4
    Two-Headed Nature of Myosin
    • 4.1
      Are the Two Myosin Heads Identical?
    • 4.2
      Interactions of the Two Myosin Heads
  • 5
    Molecular Mechanism of Cross-Bridge Cycle
    • 5.1
      Segmental Flexibility of Myosin
    • 5.2
      Measurement of Correlation Time
    • 5.3
      Local Fluctuations in Myosin Structure
  • 6
    Organized Systems
    • 6.1
      Motion of Myosin Heads
    • 6.2
      Orientation of Myosin Heads
  • 7
    Force Generation and Elasticity
    • 7.1
      Rotating-Head Models
    • 7.2
      Helix-Coil Melting Model
    • 7.3
      Actin Motions
    • 7.4
      X-Ray Studies
    • 7.5
      Correlation Functions