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Diseases of Skeletal Muscle

Handbook of Physiology, Skeletal Muscle

  1. R. H. T. Edwards,
  2. D. A. Jones

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp100120

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Edwards, R. H. T. and Jones, D. A. 2011. Diseases of Skeletal Muscle. Comprehensive Physiology. 633–672.

Author Information

  1. Department of Medicine, Faculty of Clinical Science, University College London, London, England

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    History
  • 2
    Clinical Presentation of Muscle Disease
    • 2.1
      Weakness
    • 2.2
      Fatigue
    • 2.3
      Myoglobinuria
    • 2.4
      Unusual Function
  • 3
    Investigation of Patients with Muscle Disease
    • 3.1
      Clinical History and Examination
    • 3.2
      Blood Biochemistry
    • 3.3
      Electromyography
    • 3.4
      Muscle Biopsy
    • 3.5
      Nuclear Magnetic Resonance
    • 3.6
      Measurement of Muscle Cross-Sectional Area
    • 3.7
      Tests of Muscle Function
    • 3.8
      Isolated Human Muscle Preparations
    • 3.9
      Exercise and Fasting as Provocation Tests
    • 3.10
      Sudies of Protein Turnover
  • 4
    Analysis of Muscle Weakness
    • 4.1
      Dystrophies
    • 4.2
      Inflammatory Myopathies
    • 4.3
      Atrophy and Hypertrophy
    • 4.4
      Factors Affecting Protein Turnover in Muscle
    • 4.5
      Neuropathies
  • 5
    Analysis of Abnormal Fatigability
    • 5.1
      Muscle Fatigue in Normal Subjects
    • 5.2
      Myasthenia Gravis
    • 5.3
      Disorders of Energy Metabolism
    • 5.4
      Disorders of Mitochondrial Oxidative Metabolism
    • 5.5
      Disorders of Fat Metabolism
    • 5.6
      Changes in Muscle Function
  • 6
    Disordered Function
    • 6.1
      Myotonic Syndromes
    • 6.2
      Periodic Paralysis
    • 6.3
      Malignant Hyperpyrexia
    • 6.4
      Muscle Pain, Cramps, and Contractures
  • 7
    Drug-Induced Myopathies
  • 8
    Mechanisms Underlying Muscle Disease
    • 8.1
      Vascular and Humoral Influences
    • 8.2
      Influence of Nerve on Muscle
    • 8.3
      Disorders of the Cell Membrane
    • 8.4
      Muscle Protease Activity
    • 8.5
      Inflammatory Disorders of Muscle
    • 8.6
      Overuse and Disuse as Causes of Muscle Damage
  • 9
    Prospects For Treatment of Muscle Disease