Standard Article

Animal Models

Handbook of Physiology, Aging

  1. Richard Weindruch

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp110103

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Weindruch, R. 2011. Animal Models. Comprehensive Physiology. 37–52.

Author Information

  1. Department of Medicine, University of Wisconsin and Veterans Administration — Geriatric Research Education and Clinical Center, Madison, Wisconsin

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Selection of an Appropriate Animal Model
    • 1.1
      Animal Models and the Main Ways of Studying Aging
    • 1.2
      Defined Longevity Characteristics
    • 1.3
      Awareness of Late-Life Disease Patterns
    • 1.4
      Defined Environmental Conditions
    • 1.5
      Diet
    • 1.6
      Genetic Characteristics
    • 1.7
      Availability and Cost
  • 2
    Patterns of Animal Use in Aging Studies
    • 2.1
      Animal Use in Aging Research, 1972–1992
    • 2.2
      Overuse of the Male Fischer 344 Rat
  • 3
    Need for the Use of a Wide Spectrum of Models
    • 3.1
      Lessons from Nonmammals
    • 3.2
      Rodents
    • 3.3
      Carnivores
    • 3.4
      Nonhuman Primates
  • 4
    Summary and Conclusions