Standard Article

Cell Culture as a Model

Handbook of Physiology, Aging

  1. Vincent J. Cristofalo,
  2. Robert J. Pignolo

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp110104

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Cristofalo, V. J. and Pignolo, R. J. 2011. Cell Culture as a Model. Comprehensive Physiology. 53–82.

Author Information

  1. Center for Gerontological Research, Medical College of Pennsylvania, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Historical Development of Cell Cultures for the Study of Aging
  • 2
    Relevance of in Vitro Cellular Senescence to in Vivo Aging
    • 2.1
      Cell Cultures as Models
    • 2.2
      Cellular Mortality, Cellular Clocks, and Death as an End Point for Aging
    • 2.3
      Aging and Evolution
    • 2.4
      In Vivo–In Vitro Parallel Changes
  • 3
    Caveats in the Use of Cell Cultures as Models
  • 4
    Cellular and Molecular Markers of Senescence in Vitro and in Vivo
  • 5
    Mechanistic Studies of in Vitro Replicative Senescence
    • 5.1
      Stochastic Mechanisms
    • 5.2
      Signal Transduction Pathways
    • 5.3
      Genetic Mechanisms
  • 6
    Summary and Conclusions