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Aging of Long-Lived Proteins: Extracellular Matrix (Collagens, Elastins, Proteoglycans) and Lens Crystallins

Handbook of Physiology, Aging

  1. David R. Sell,
  2. Vincent M. Monnier

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp110110

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Sell, D. R. and Monnier, V. M. 2011. Aging of Long-Lived Proteins: Extracellular Matrix (Collagens, Elastins, Proteoglycans) and Lens Crystallins. Comprehensive Physiology. 235–305.

Author Information

  1. Institute of Pathology, Case Western Reserve University, Cleveland, Ohio

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Collagens
    • 1.1
      Overview
    • 1.2
      Methodological Difficulties in the Assessment of Collagen Changes during Aging
    • 1.3
      Hypertension and Collagen Deposition in Relation to the Aging Process
    • 1.4
      Turnover of Collagen
    • 1.5
      Physical Properties of Aging Collagen
    • 1.6
      Measurement of the Physical Properties of Collagen as Potential Biomarkers of Aging
    • 1.7
      Chemical Properties of Aging Collagen
  • 2
    Elastin
    • 2.1
      Molecular Contrasts between Elastin and Collagen
    • 2.2
      Morphological Changes in Elastin with Aging
    • 2.3
      Quantitative Changes in Elastin with Aging
    • 2.4
      Conclusions
  • 3
    Proteoglycans
    • 3.1
      Biochemical Composition
    • 3.2
      Aggregating and Nonaggregating Populations of Proteoglycans
    • 3.3
      Age-Related Changes in Proteoglycans
    • 3.4
      Conclusions
  • 4
    Lens Crystallins
    • 4.1
      Overview
    • 4.2
      Age-Related Changes in Lens and Lens Crystallins
    • 4.3
      Changes in Enzyme Activity
    • 4.4
      Mechanisms of Crystallin Aging
    • 4.5
      Conclusions
  • 5
    Summation