Standard Article

Loss of Integration and Resiliency with Age: A Dissipative Destruction

Handbook of Physiology, Aging

  1. F. Eugene Yates,
  2. Laurel A. Benton

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp110122

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Yates, F. E. and Benton, L. A. 2011. Loss of Integration and Resiliency with Age: A Dissipative Destruction. Comprehensive Physiology. 591–610.

Author Information

  1. Department of Medicine, University of California, Los Angeles, California

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Senescence
    • 1.1
      Models in Science
    • 1.2
      Senescence Is Not the Same as Aging
    • 1.3
      What Senesces?
    • 1.4
      System Death or Component Death
  • 2
    Regular Phenomena
    • 2.1
      Increases in Regularity with Senescence
    • 2.2
      Regularity of a Variable's Time History
  • 3
    Physical Background of Senescence
    • 3.1
      Complexity
    • 3.2
      Order
    • 3.3
      Vertical Integration (Hierarchy)
    • 3.4
      Horizontal Integration (Heterarchy)
    • 3.5
      Causality
    • 3.6
      Stability
    • 3.7
      Energy vs. Entropy in Self-Organization
  • 4
    General Principle of Homeodynamic Senescence
    • 4.1
      Homeodynamics Instead of Homeostasis
    • 4.2
      Irreversibility and Constraints
    • 4.3
      Biological Markers of Age
  • 5
    Homeodynamics and Predictability
    • 5.1
      Specifying the Homeodynamic Construct
    • 5.2
      Fluctuations and Chance
  • 6
    Counterintuitive Effects of Clamping a Homeodynamic System
    • 6.1
      Environmental Potentials
    • 6.2
      Clamping
  • 7
    Redefinition of Senescence
    • 7.1
      Escape from Senescence-Induced Fatal Failures by Re-Initialization
    • 7.2
      Summary of Characteristics of Senescence as Homeodynamic Instability
  • 8
    Aspects of Senescence
    • 8.1
      Aspect Theories
    • 8.2
      Generalizations from Aspect Theories
  • 9
    Wear-and-Tear Revisited
    • 9.1
      Reliability Theory for Machines
  • 10
    Human Senescence as Dissipative Destruction
    • 10.1
      Component Failure–Cell Culture Senescence
    • 10.2
      Dissipative Destruction as Basis of Gompertz Mortality Kinetics
  • 11
    Summary