Standard Article

Lactate Transport and Exchange During Exercise

Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems

  1. L. Bruce Gladden

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp120114

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Gladden, L. B. 2011. Lactate Transport and Exchange During Exercise. Comprehensive Physiology. 614–648.

Author Information

  1. Department of Health & Human Performance, Auburn University, Auburn, Alabama

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Why Does [La] Increase During Exercise?
    • 1.1
      Muscle Hypoxia: The Traditional Hypothesis
    • 1.2
      Evidence Against Muscle Hypoxia
    • 1.3
      Multiple Factors
    • 1.4
      Criticism of Evidence Against O2-limitation
    • 1.5
      Near-Equilibrium Steady State: A Unifying Hypothesis?
    • 1.6
      Summary
  • 2
    The Lactate Shuttle
  • 3
    Carrier-Mediated Lactate Transport
    • 3.1
      Lactate Transport in Sarcolemmal Vesicles
    • 3.2
      Lactate Transport in Isolated Cells
    • 3.3
      Reconstitution of the Lactate Carrier
    • 3.4
      Lactate Transport In Situ
    • 3.5
      Summary
  • 4
    Muscle as a Consumer of Lactate: Regulating Factors
    • 4.1
      Lactate Concentration
    • 4.2
      Metabolic Rate
    • 4.3
      Blood Flow
    • 4.4
      Hydrogen Ion Concentration
    • 4.5
      Muscle Fiber Type
    • 4.6
      Exercise Training
    • 4.7
      Summary
  • 5
    Blood Transport of Lactate
    • 5.1
      Lactate Distribution between Plasma and RBCs
    • 5.2
      Comparative Aspects of Lactate Transport in RBCs
  • 6
    Altitude
    • 6.1
      The Lactate Paradox
    • 6.2
      Explanations for the Lactate Paradox
    • 6.3
      Summary