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Control of Glycolysis and Glycogen Metabolism

Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems

  1. Richard J. Connett1,
  2. Kent Sahlin2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp120119

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Connett, R. J. and Sahlin, K. 2011. Control of Glycolysis and Glycogen Metabolism. Comprehensive Physiology. 870–911.

Author Information

  1. 1

    Department of Physiology, University of Rochester School of Medicine and Dentistry, & Department of Biological Sciences, Monroe Community College, Rochester, New York

  2. 2

    Department of Physiology and Pharmacology, Karolinska Institute and Department of Sports and Health Sciences, University College of Physical Education, Stockholm, Sweden

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Importance of Glycolysis in Skeletal Muscle at Rest and During Exercise
  • 2
    General Overview of the Glycolytic Pathway
    • 2.1
      ATP Supply
    • 2.2
      Support of Other Metabolic Needs
  • 3
    Properties of Glycogen and Associated Enzymes
    • 3.1
      Structure of Glycogen
    • 3.2
      Control of GP
    • 3.3
      Control of GS
    • 3.4
      Integrated Control of GP and GS During Exercise
  • 4
    Other Specific Glycolytic Enzyme Controls
    • 4.1
      Equilibrium Group
    • 4.2
      Phosphofructokinase
    • 4.3
      Aldolase
    • 4.4
      Glyceraldehydephosphate Dehydrogenase and Phosphoglycerate Kinase (PGK)
    • 4.5
      Phosphoglycerate Mutase and Enolase
    • 4.6
      Pyruvate Kinase
    • 4.7
      Lactate Dehydrogenase
  • 5
    Carbohydrate Utilization at Rest and During Exercise
    • 5.1
      Diurnal Variations of Body Stores at Rest
    • 5.2
      CHO Utilization during Exercise
    • 5.3
      Control of Glycogenolysis during Heavy Exercise
  • 6
    Postexercise Glycogen Synthesis and its Control
    • 6.1
      Resynthesis of Muscle Glycogen After Exercise
    • 6.2
      Regulatory Mechanisms
  • 7
    Muscle Glycogen Metabolism and Fatigue
    • 7.1
      Importance of CHO during Prolonged Exercise
    • 7.2
      Importance of Glycogen during High-Intensity Exercise
  • 8
    Integrative Aspects of Glycolytic Control and Future Directions (K. Sahlin)
    • 8.1
      Rest-Work Transition
    • 8.2
      Future Directions
  • 9
    Integrative Aspects of Glycolytic Control and Future Directions (R. J. Connett)
    • 9.1
      Systems Analysis
    • 9.2
      Cellular Oxygen Tension and Lactate Formation
    • 9.3
      Summary
    • 9.4
      State of the Phosphate Energy System
    • 9.5
      Cytosolic pH
    • 9.6
      Substrate Effects
    • 9.7
      Future Directions