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Lipid Metabolism in Muscle

Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems

  1. Ger J. Van Der Vusse,
  2. Robert S. Reneman

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp120121

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Van Der Vusse, G. J. and Reneman, R. S. 2011. Lipid Metabolism in Muscle. Comprehensive Physiology. 952–994.

Author Information

  1. Departments of Physiology and Motion Sciences, Cardiovascular Research Institute Maastricht, University of Limburg, Maastricht, The Netherlands

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Supply and Cellular Uptake of Upids in Skeletal Muscles
    • 1.1
      Albumin-Bound Fatty Acids
    • 1.2
      Fatty Acids in Circulating Lipoproteins
    • 1.3
      Skeletal Muscle Fatty Acid Uptake
  • 2
    Fatty Acid Metabolism in the Skeletal Muscle Cell
    • 2.1
      Activation and Oxidation of Fatty Acids
    • 2.2
      Intramuscular Triacylglycerols
  • 3
    Supply and Utilization of Upids During Exercise
    • 3.1
      Albumin-Bound Fatty Acids in Plasma during Exercise
    • 3.2
      Circulating Lipoprotein-Triacylglycerols as a Potential Source of Fatty Acids during Exercise
    • 3.3
      Contribution of Intramuscular Triacylglycerols to Fatty Acid Oxidation during Exercise
    • 3.4
      Relative Contribution of Various Sources of Lipids to Overall Fatty Acid Utilization during Exercise
    • 3.5
      Gender Differences in Lipid Utilization during Exercise
  • 4
    Effect of Training on Skeletal Muscle Lipid Utilization
    • 4.1
      Advantages of Enhanced Lipid Utilization by Trained Muscles during Exercise
    • 4.2
      Possible Causes of Increased Lipid Consumption by Trained Muscles during Exercise
    • 4.3
      Utilization of Plasma-Borne Fatty Acids by Trained Muscles
    • 4.4
      Circulating Lipoproteins as an Additional Source of Lipids for Trained Muscles
    • 4.5
      Utilization of Intramuscular Triacylglycerols in Endurance-Trained Muscles
    • 4.6
      Regulation of Fatty Acid Release from Intramuscular Triacylglycerols in Trained Muscles
  • 5
    Effect of Diet on Muscle Lipid Metabolism
    • 5.1
      High-Carbohydrate vs. High-Fat Diets in Relation to Physical Performance
    • 5.2
      Shift from Carbohydrate to Lipid Utilization by High-Fat Diet
    • 5.3
      Source of Lipid for Muscles during High-Fat Diet Feeding
    • 5.4
      Possible Mechanisms Underlying Increased Muscular Lipid Utilization during High-Fat Feeding
  • 6
    Interrelationship Between Muscular Carbohydrate and Lipid Metabolism
    • 6.1
      The Glucose–Fatty Acid, or Randle, Cycle
    • 6.2
      The Existence of the Randle Cycle in Skeletal Muscle
    • 6.3
      Possible Mechanisms Underlying the Glucose-Fatty Acid Cycle in Skeletal Muscle
    • 6.4
      A Role for Malonyl CoA in Fuel Selection in Skeletal Muscle Cells
  • 7
    Defects in the Skeletal Muscle Fatty Acid Oxidative Pathway
  • 8
    Concluding Remarks