Standard Article

Regulation of Gene Expression in Skeletal Muscle by Contractile Activity

Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems

  1. R. Sanders Williams,
  2. P. Darrell Neufer

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp120125

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Williams, R. S. and Neufer, P. D. 2011. Regulation of Gene Expression in Skeletal Muscle by Contractile Activity. Comprehensive Physiology. 1124–1150.

Author Information

  1. Departments of Internal Medicine and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Theoretical and Kinetic Considerations
  • 2
    Experimental Systems and Models for Study of Gene Regulation by Contractile Activity
    • 2.1
      Human Investigations
    • 2.2
      Animal Studies
    • 2.3
      Studies in Cell Culture
  • 3
    What Genes are Regulated by Contractile Activity?
    • 3.1
      Sarcomeric Proteins
    • 3.2
      Enzymes of Glycolysis
    • 3.3
      Mitochondrial Proteins
    • 3.4
      Transcription Factors
    • 3.5
      Growth Factors and Receptors
  • 4
    Mechanisms of Gene Regulation
    • 4.1
      Definitions
    • 4.2
      Transcription
    • 4.3
      RNA Processing, Targeting, and Stability
    • 4.4
      Translational and Posttranslational Control
  • 5
    Messengers and Signal Transduction Pathways
    • 5.1
      Calcium
    • 5.2
      Hydrogen Ion
    • 5.3
      Energy Charge/Phosphorylation Potential
    • 5.4
      Redox Potential
    • 5.5
      Oxygen Tension
    • 5.6
      Mechanical Stretch
    • 5.7
      Receptor Linked Signaling Pathways
  • 6
    Special Pathways for Control of Mitochondrial Genes
  • 7
    Conclusions