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Cellular, Molecular, and Metabolic Basis of Muscle Fatigue

Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems

  1. Robert H. Fitts

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp120126

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Fitts, R. H. 2011. Cellular, Molecular, and Metabolic Basis of Muscle Fatigue. Comprehensive Physiology. 1151–1183.

Author Information

  1. Department of Biology, Marquette University, Milwaukee, Wisconsin

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Definition and Current Theories of Fatigue
  • 2
    Muscle Fiber-Type Composition
  • 3
    Mechanical Properties
    • 3.1
      The Isometric Contractile Properties
    • 3.2
      The Maximal Shortening Speed and Peak Power
    • 3.3
      The Force-Frequency Relationship
  • 4
    Excitation-Contraction Coupling
    • 4.1
      Sarcolemma and T-Tubular Membranes
    • 4.2
      T-Tubular–Sarcoplasmic Reticulum Junction and Calcium Release
  • 5
    Lactic Acid, Intracellular pH And Fatigue
    • 5.1
      Muscle Lactate
    • 5.2
      Hydrogen Ion and Muscle Fatigue
  • 6
    Inorganic Phosphate and Muscle Fatigue
    • 6.1
      Total Phosphate and the Diprotonated Form
    • 6.2
      Mechanisms of Phosphate Action
  • 7
    High-Energy Phosphates and the Free Energy of ATP Hydrolysis
    • 7.1
      ATP and Muscle Fatigue
  • 8
    Blood Glucose and Muscle Glycogen
    • 8.1
      Hypoglycemia and Performance
    • 8.2
      Carbohydrate Metabolism and Muscle Fatigue
  • 9
    Ultrastructural Changes and Muscle Fatigue
    • 9.1
      Muscle Damage and Exercise Intensity
    • 9.2
      Organelle Susceptibility to Damage
  • 10
    Summary and Conclusions