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Principles of Regulation and Control in Biochemistry: A Pragmatic, Flux-Oriented Approach

Handbook of Physiology, Cell Physiology

  1. B. Crabtree1,
  2. E. A. Newsholme2,
  3. N. B. Reppas3

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp140105

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Crabtree, B., Newsholme, E. A. and Reppas, N. B. 2011. Principles of Regulation and Control in Biochemistry: A Pragmatic, Flux-Oriented Approach. Comprehensive Physiology. 117–180.

Author Information

  1. 1

    Rowelt Research Institute, Aberdeen, Scotland

  2. 2

    Merton College, University of Oxford, Oxford, England

  3. 3

    Balliol College, University of Oxford, Oxford, England

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Flux-Oriented Theory of Regulation
    • 1.1
      Flux-Generating Steps
    • 1.2
      Branched Fluxes: Reversible Reactions
    • 1.3
      Other Types of Flux: Energy Fluxes and Equivalence
    • 1.4
      Internal and External Effectors
    • 1.5
      Control and Regulation of Metabolic Fluxes and Concentrations: Communication and Regulatory Sequences
    • 1.6
      Control Versus Regulation
    • 1.7
      Identification of Communication Sequences In Vivo
    • 1.8
      Need for Sensitive Regulation In Vivo
    • 1.9
      Metabolic Sensitivities
    • 1.10
      Analysis of Non-Steady States
  • 2
    Two Other Important Approaches to Metabolic Control and Regulation
    • 2.1
      Biochemical Systems Theory (BST)
    • 2.2
      Metabolic Control Theory (MCT)
  • 3
    Summary and Future Prospects